In recent years,the innovation and entrepreneurship has become the theme of development of higher education in the world and key project,how to develop effective and innovative education,cultivate creative talents for the national development,became the focus of attention.Innovation and entrepreneurship education in China may be assimilated into the biosphere,analysis on inharmonious factors in the ecosystem of innovation and entrepreneurship education,including the University’s understanding of its simplicity,less attention to them,implementation,lack of resources,and so on.Proposed building the harmonious ecosystem of innovation education in colleges and universities in China route,accelerating the transformation of innovation and entrepreneurship education,building a high-quality innovation and entrepreneurship education and professional education,”the combination of production,study and research” path of development,improve the system environment.