Phenomenon of college students' migrant workers reflects the problems of university talents training mode to a certain extent. According to Burton Clark's the triangle model, the discipline that as a basic unit of universities talents training break away from the market. Based on this basic judgment, drawing on the concept of entrepreneurial university and highlighting the entrepreneurial spirit of entrepreneurial discipline is a core element to solve the problem of cultivating college students. Based on the Entrepreneurial Discipline for the reform of university talents training mode is a worth thinking direction, including three of which need to pay attention: Examining the university talents training mode from the perspective of interdisciplinary; Cultivating students' practical innovation ability through discipline; The establishment of professional team of teachers and teachers of the industry integration of university talents training teachers.