QQ is the most popular instant messaging for online chatting in China. This research attempts to examine the influence of QQ interpersonal communication to the relationship and loneness, and to construct the model of QQ interpersonal communication by the method of path analysis from 182 college students. The results show that QQ interpersonal communication can go into deep communication by the help of internet nonverbal emoticons, and deep communication can motivate self-disclosure so as to influence the relationship. Moreover, motivation and deep communication can both influence behavior of QQ interpersonal communication, in turn to weaken the loneness. However, behavior of qq interpersonal communication can not influence the relationship. this research construct the qq interpersonal communication model including verbal information, nonverbal emoticons, psychological variables, behaviors, and show the function and meaning of Computer-mediated Communication.