During the Edo period, the Tokugawa shogunate in Japan attached great importance to Neo-confucianism and regarded it as an official doctrine at that time. At present, many studies have discussed the special significance of carrying out Neo-confucianism under the background of the Edo period, but there is a lack of precedent combining Zhu Xi's works. Therefore, this paper focuses on the interpretation of Bailudong academy revelation written by Zhu Xi and widely annotated in Japan, and analyzes the core content of Neo-confucianism from the perspectives of religious belief, situation change and class form in the Edo period, and then demonstrates the significance of Neo-confucianism being carried out in the Edo period.